Unless your whole motor is new, no. If you changed jugs pistons. ect. then you would break it in but just cams and lifters they won't need any break-in time, although i wouldn't red line it for a few miles either.
A lot. I was surprised by the valve train noise at first, but after 500 miles on the build she's quiet down some. I put the S&S 583 cams in. Good linear torque with no flat spots. Adjustable push rods which actually needed another 1/2 turn from spec.