I don't see why not

 

I have Cobras on my Road King and like them a lot, but from the link Imold posted, it looks like I need more pressure in them.

 

Any modern 'tubeless' tyre will also take a tube, the days when there were different tyres for both applications are way behind us. As for tyre pressures, when changing away from stock brand always check your new tyre's website. Some brands will be the same as stock, but others are different, including Avon. If they are run low they are likely to wear fast!

Cobras replace Venoms and I much prefer Avons to many other brands. They give good grip in all conditions and are compliant giving a good quality ride, things that are more important to me than a few more miles. I've been using Avons on my Harleys since the '70s and always go back to them!