Tighten it till the threads strip completely off...... then back it up half turn.
NO just kidding , Dawg hit it right on the head. check the bearings and seals for any unusual wear, put it back with the "right" spacers for your application ( in the correct arrangement), torque down to about 105 ft/lb, spin wheel if off the ground, loosen and retighten to about 95 ft/lb.
be sure to replace castle nut pin if so equipped. very straight forward, don't let it "fear ya" good luck
John