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For best overall performance a 2-into-1 will fit the bill. I have an S&S 107" with SuperTrapp Supermeg. Excellent smooth torque and reasonable sound. Some of the other options are just too darned loud IMHO. My wife and I do long tours and love it!
I actually have a CVO RG & installed the RB black hole spyder. My wife & I put 2400+ miles on it touring the coast last month & it wasn't obnoxiously loud. The performance was much better than the V&H pro-pipe I originally had on the bike.