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I'm using them with road king bags on my deluxe an the brackets sit at an angle so they kick the bottom of the bags out a little, I would think they'd clear with out any problems but that's my opinion based on my bags!
I had them on my last bike - a Vulcan 900. They work, well, but they set the bags pretty far out from the fender. I had Saddlemen Express Cruis'n bags with them too. Because the bags weren't so deep, and the easy brackets set them so far out from the fender, I thought they looked more like wings than saddlebags.
Saddlemen bags with EZ-Brakets. Very easy to install. I use the bags for weekend trips. Once we get to the destination, the bags come off. I have no issues with clearance on either side of the bike. (The picture in my sig was taken at the same time. Stripped the bike down for some better pics.)