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Yes, they will all work on a bike. Some of the advantages for a bike friendly gps are better mounting system. More secure to stay attached to the bike. Waterproof, more shock resistant and easier to use with gloves on.
Many people use automobile gps with good results. It can be done. It just depends on what you are willing to spend for whatever features are offered.
But one must understand the definition of "works." Many automotive units are not weather resistant...get them wet or dust-covered and they may never work again.
In addition, some use a "hard drive" and cannot withstand the vibrations generally found on a motorcycle.
Others have screens that simply "wash out" in bright sunlight and become all but useless on a bike.
Which one? You need to be more specific. If you are talking about the external one then definately not. It's a Garmin Quest. The factory internal unit is also a very pricey for what you get. Feature for feature and for price, a Garmin Zumo kicks it's ***. Here's the kicker, I got the factory one for my Ultra because it's completely internal. Gets me where I want to go without anything hanging on my bars and is with me all the time. The Quest I use on my Wideglide. I also have a street pilot and two Nissan built in factory units for my cages and I can honestly say they all work fine. Different bells and whistles but you aoint getting lost with any of these.
ecost.com has the Garmin Quest for $64.95. It's not the newest nor does it have all the bells and whistles but mine does everything I need to do and you can't beat the price. It's the same unit as the Harley Quest. Its waterproof.
BTW I'm in no way associated with ecost just thought you might want to know.
The Zumo 550 is really made for the motorcycle...and I agree, it can be purchased for several hundred less than the HD model via Amazon.com. That's what I did.
I had a Delphi car XM radio last season that I hooked to bike with special RAM mount and weather proof clear cover.
By the end of the season, it wasn't working all that well, and this is the main reason I went to Garmin Zumo. I get GPS and XM radio and MP3 but in a much more rugged configuration. Let's face it, our HD twins shake, rattle and roll, and we need that ruggedness
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