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Typically, the thicker grips are going to be more comfy. This is due to the fact that the thinner the grip is the more you have to actually squeeze your hand to grasp it.In turn, your not squeezing your hand as much with a fatter grip causing less muscle fatigue.
A lot of people really like ISO grips. i really like X2 grips they are squareish. and fit my hands better. It all depends on your hand and what you think
After riding with the large version of Harley's Chrome and Rubber grips on my Softail for almost 5 years, I'm finding that the small, stock grips onmy 883C I picked up a couple days ago are making my hands cramp. I'm going to larger grips asap.