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This past weekend I removed my HD radio and installed a Sony CDX GT-720 head unit with Sirius radio, a Blaupunkt THA275PNP 75W x 2 amplifier, and 4 Polk Momo MMC 525 5-1/4" 2-way speakers. I used the Hawg Wired installation kit and adapter harness to retain the handlebar controls.
My previous system was Hogtune front and rear speakers with their amp. It sounded pretty good but I wanted satellite radio and a Sony unit so I removed the whole system.
The amp is a 2 channel amp. I was limited with space since I installed everything under the fairing. That is why I didn't go with a 4 channel amp. I wired the speakers so that the amp runs in a 2 ohm load. It is rated to handle this.