To get started run 43 over to 39/51. Once on 39/51 south you can get head east on a few different two lanes. Avoids all of the 94 crap and Chicago. Decide if you want to run south to KY/TN 51 south is two lane most of the way then east on two lane several options. Or two lane Indiana get over and run 25 in KY and parts of the Cumberland gap, great ride.
Running 25 south from Cincinnati follows 75 and has some great riding. And if you want stay on 75 to Lexington the get on 25 and ride.

 

Go into Google Maps and turn on options to avoid highways and toll roads, I can't get the map to share what i did but I used these towns to create a map, Lake Geneva - Forrest Il. - Kentland In. - Evansville In. - Bowling Green Ky. - Athens Tn. that would put you very near Tellico Plains

 

 

If you want an interesting route. use the options in the HD GPS to take you on two lanes and scenic routes. What I like to call roads you never saw before trip. We have had some interesting riding doing that. Say you want to be in Knoxville some time today but do care how you get there. Just plug in HD dealer in Knoxville and let it get you there with side roads. You will get there and have an interesting ride.