Were I to increase throttle body to larger size, with a free flow air cleaner, would I need to change injectors? All stock now.

 

No, but it would need tuned, as the amount of airflow per degree of throttle opening would be different.

 

Hello, I'm from NC and have a 2016 CVO Street Glide. I have RC Tru Duals and SE Tuner. I am thinking of changing cams to either Fuel Reaper 594s or SE 585s. I would love to hear your thoughts,

 

E6 when I installed my stage 4 and fired it up I went for a test ride and it did exactly what you described until I changed the tune with the SERT. That's why they sell it as part of the kit. Sounds like you need one

 

I had some work done and ended up with a short that ruined my tune. I noticed the bike ran rough, would not idle was getting about 26mpg. I found someone to clear the tune out of the ECM and completely retune the bike. I think before I spent more money on parts I would find a good tuner and put him to work. Could save you a lot of money down the road.
Good luck