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I'll tell you what fatigued me. Sitting on top of my Road Glide and leaning forward and down to reach the bars. I put a seat on that lowered me 11/4" and set me further back 1". 13" apes and now I can put 600 miles a day on easily!
The apes are absolutely comfy. The stock bars hurt my back and the 16's are very natural. My hands are shoulder height or just below and I would agree that higher could get uncomfortable on a long ride. 300+ miles is not an issue.
I have Wild 1's 513's on my 08 RG. I'm kinda happy with them, but feel at 35 or so inches, they are too wide for me. I also wanted a bit more rise in the bars. I thought about 515's, but they are definitely too wide. Maybe Wild 1's RG bars at 31 inches wide, would fit the bill. Handlebars are a bitch too get right.... Thank God for Ebay.