Yes and no. To my knowledge they're still working on getting something like an ECM replacement tuners (MasterTune) to work, but things like Power Vision or Fuel Paks do work with a minor caveat. I have to pull the radio fuse when I flash a tune to the bike, which lets go of the hold that the Maestro has on the ECM to allow that flash, the gauges feature on the radio locks down the ECM and wont allow a flash otherwise. Soundstream says they fixed that in a Maestro firmware update and it should only lock down the ECM when the gauges are actively being displayed, but that's never worked for me. Otherwise, the PV works perfectly fine when connected, it's only when you flash a tune do you need to pull that fuse.