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I dont shift to 6th until around 75. Lugging the engine is way harder on it than rolling it in the sweet spot RPM range. If you are at 1500 RPM in the twisties, you are definitely lugging the motor, that is unless you are going down hill.
1800-2200 RPM when cruising at lower speeds unless going up a grade or need to accelerate rapidly. I like the deep, low authoratative rumble and the 107", with the performance combination installed it is not lugging the engine, still has plenty of acceleration. Some of the people I ride with are always reving like they are riding a ricer, now that is extra wear and tear on a Harley engine.